http://zappajs.org/

Zappa is a CoffeeScript DSL-ish interface for building web apps on the node.js
runtime, integrating express, socket.io and other best-of-breed libraries.

https://github.com/tcr/rem-js

REM is a REST library that does away with excessive configuration, confusing
authentication, and incomplete libraries. Whether using an existing API or
writing your own, REM is the fewest lines of code between reading documentation
and getting started. And with support for popular services built-in, you might
never need another web service library.